Replication protein A is required for meiotic recombination in Saccharomyces cerevisiae.

@article{Soustelle2002ReplicationPA,
  title={Replication protein A is required for meiotic recombination in Saccharomyces cerevisiae.},
  author={Christine Soustelle and M. Vedel and Richard Kolodner and Alain Nicolas},
  journal={Genetics},
  year={2002},
  volume={161 2},
  pages={535-47}
}
In Saccharomyces cerevisiae, meiotic recombination is initiated by transient DNA double-stranded breaks (DSBs). These DSBs undergo a 5' --> 3' resection to produce 3' single-stranded DNA ends that serve to channel DSBs into the RAD52 recombinational repair pathway. In vitro studies strongly suggest that several proteins of this pathway--Rad51, Rad52, Rad54, Rad55, Rad57, and replication protein A (RPA)--play a role in the strand exchange reaction. Here, we report a study of the meiotic… CONTINUE READING

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