Replication protein A (RPA): the eukaryotic SSB.

  title={Replication protein A (RPA): the eukaryotic SSB.},
  author={Cristian Borcea Akhilesh Saxena Deepa Iyer Porlin Kang Rabi Iftode and Yaron Daniely and James A. Borowiec},
  journal={Critical reviews in biochemistry and molecular biology},
  volume={34 3},
Replication protein A (RPA) is a heterotrimeric single-stranded DNA-binding protein that is highly conserved in eukaryotes. RPA plays essential roles in many aspects of nucleic acid metabolism, including DNA replication, nucleotide excision repair, and homologous recombination. In this review, we provide a comprehensive overview of RPA structure and function and highlight the more recent developments in these areas. The last few years have seen major advances in our understanding of the… CONTINUE READING
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