Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex.

@article{Dueber2007ReplicationOR,
  title={Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex.},
  author={Erin L Cunningham Dueber and Jacob E Corn and Stephen D Bell and James M Berger},
  journal={Science},
  year={2007},
  volume={317 5842},
  pages={1210-3}
}
The faithful duplication of genetic material depends on essential DNA replication initiation factors. Cellular initiators form higher-order assemblies on replication origins, using adenosine triphosphate (ATP) to locally remodel duplex DNA and facilitate proper loading of synthetic replisomal components. To better understand initiator function, we determined the 3.4 angstrom-resolution structure of an archaeal Cdc6/Orc1 heterodimer bound to origin DNA. The structure demonstrates that, in… CONTINUE READING

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