Replication of the association between CHRNA4 rs1044396 and harm avoidance in a large population-based sample.

Abstract

Harm avoidance is a personality trait characterized by excessive worrying and fear of uncertainty, which has repeatedly been related to anxiety disorders. Converging lines of research in rodents and humans point towards an involvement of the nicotinic cholinergic system in the modulation of anxiety. Most notably, the rs1044396 polymorphism in the CHRNA4… (More)
DOI: 10.1016/j.euroneuro.2015.11.007

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