Replication of modified vaccinia virus Ankara in primary chicken embryo fibroblasts requires expression of the interferon resistance gene E3L.

@article{Hornemann2003ReplicationOM,
  title={Replication of modified vaccinia virus Ankara in primary chicken embryo fibroblasts requires expression of the interferon resistance gene E3L.},
  author={Simone Hornemann and Olof Harlin and Caroline Staib and Sigrid Kisling and Volker Prof. Dr. Erfle and Bernd Kaspers and Georg H{\"a}cker and Gerd Sutter},
  journal={Journal of virology},
  year={2003},
  volume={77 15},
  pages={
          8394-407
        }
}
Highly attenuated modified vaccinia virus Ankara (MVA) serves as a candidate vaccine to immunize against infectious diseases and cancer. MVA was randomly obtained by serial growth in cultures of chicken embryo fibroblasts (CEF), resulting in the loss of substantial genomic information including many genes regulating virus-host interactions. The vaccinia virus interferon (IFN) resistance gene E3L is among the few conserved open reading frames encoding viral immune defense proteins. To… CONTINUE READING

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