Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism.

@article{Brown2005ReplicationOM,
  title={Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism.},
  author={Timothy A. Brown and Ciro Cecconi and Ariana N. Tkachuk and C. Bustamante and D. A. Clayton},
  journal={Genes & development},
  year={2005},
  volume={19 20},
  pages={2466-76}
}
The established strand-displacement model for mammalian mitochondrial DNA (mtDNA) replication has recently been questioned in light of new data using two-dimensional (2D) agarose gel electrophoresis. It has been proposed that a synchronous, strand-coupled mode of replication occurs in tissues, thereby casting doubt on the general validity of the "orthodox," or strand-displacement model. We have examined mtDNA replicative intermediates from mouse liver using atomic force microscopy and 2D… CONTINUE READING
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