Replication of hepatitis C virus

@article{Moradpour2007ReplicationOH,
  title={Replication of hepatitis C virus},
  author={Darius Moradpour and François Penin and Charles M. Rice},
  journal={Nature Reviews Microbiology},
  year={2007},
  volume={5},
  pages={453-463}
}
Exciting progress has recently been made in understanding the replication of hepatitis C virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. The development of complete cell-culture systems should now enable the systematic dissection of the entire viral lifecycle, providing insights into the hitherto difficult-to-study early and late steps. These efforts have already translated into the identification of novel antiviral targets and the development… 
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An overview of current models of hepatitis C virus infection is given, including in vitro cell culture systems and in vivo small‐animal models, to discuss their limitations, and provide future perspectives for research directed at the prevention and cure of HCV.
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This review discusses how the recent discovery of host-encoded factors that restrict HCV infection were identified, the mechanisms by which they inhibitHCV infection and their potential contribution to viral pathogenesis.
The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection
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Insight into the structures of these proteins and the mechanisms by which they contribute to the HCV replication cycle are reviewed, and how these insights have facilitated the development of new, directly acting antiviral compounds that have started to enter the clinic are discussed.
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Emerging real-world data are demonstrating results comparable to registration trials for DAA agents, indicating the potential for eradicating HCV is on the horizon.
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