Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.

  title={Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.},
  author={Yukio Horikawa and Kazuaki Miyake and Kazuki Yasuda and Mayumi Enya and Yushi Hirota and Kazuya Yamagata and Yoshinori Hinokio and Yoshitomo Oka and Naoko Iwasaki and Yasuhiko Iwamoto and Yuichiro Yamada and Yutaka Seino and Hiroshi Maegawa and Atsunori Kashiwagi and Ken Yamamoto and Katsushi Tokunaga and Jun Takeda and Masato Kasuga},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={93 8},
BACKGROUND In Europeans and populations of European origin, several groups have recently identified novel type 2 diabetes susceptibility genes, including FTO, SLC30A8, HHEX, CDKAL1, CDKN2B, and IGF2BP2, none of which were in the list of functional candidates. OBJECTIVE AND DESIGN The aim of this study was to replicate in a Japanese population previously identified associations of single nucleotide polymorphisms (SNPs) within 10 candidate loci with type 2 diabetes using a relatively large… CONTINUE READING


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