Replication of equine herpesvirus type 1 in freshly isolated equine peripheral blood mononuclear cells and changes in susceptibility following mitogen stimulation.

@article{Meulen2000ReplicationOE,
  title={Replication of equine herpesvirus type 1 in freshly isolated equine peripheral blood mononuclear cells and changes in susceptibility following mitogen stimulation.},
  author={Karen M van der Meulen and Hans J Nauwynck and W Buddaert and Maurice B Pensaert},
  journal={The Journal of general virology},
  year={2000},
  volume={81 Pt 1},
  pages={
          21-5
        }
}
In the present study, the outcome of an inoculation of equine peripheral blood mononuclear cells (PBMC) with equine herpesvirus type 1 (EHV-1) was studied in vitro. Cytoplasmic and plasma membrane expression of viral antigens, intra- and extracellular virus titres, and plaque formation in co-culture were determined. EHV-1 replicated in monocytes, although in a highly restricted way. Viral antigens were found at maximum levels (8.7% of the monocytes) at 12 h post-infection. The infection was… CONTINUE READING

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The effect of EHV

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