Replication of damaged DNA by translesion synthesis in human cells

@article{Lehmann2005ReplicationOD,
  title={Replication of damaged DNA by translesion synthesis in human cells},
  author={A. Lehmann},
  journal={FEBS Letters},
  year={2005},
  volume={579}
}
  • A. Lehmann
  • Published 2005
  • Biology, Medicine
  • FEBS Letters
  • Most types of DNA damage block the passage of the replication machinery. In order to bypass these blocks, cells employ special translesion synthesis (TLS) DNA polymerases, which have lower stringency than replicative polymerases. DNA polymerase η is the major polymerase responsible for bypassing UV lesions in DNA and its absence results in the variant form of the genetic disorder, xeroderma pigmentosum. Other TLS polymerases have specificities for different types of damage, but their precise… CONTINUE READING

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