Replication of coxsackievirus B3 in primary cell cultures generates novel viral genome deletions.

@article{Kim2008ReplicationOC,
  title={Replication of coxsackievirus B3 in primary cell cultures generates novel viral genome deletions.},
  author={Ki-Suk Kim and Nora M Chapman and Steven Tracy},
  journal={Journal of virology},
  year={2008},
  volume={82 4},
  pages={2033-7}
}
Coxsackievirus B3 (CVB3) generates 5'-terminally deleted genomes (TDs) during replication in murine hearts. We show here that CVB3 populations with TDs can also be generated within two to three passages of CVB3 in primary, but not immortalized, cell cultures. Deletions of less than 49 nucleotides increase in size during passage, while 5' TDs of 49 nucleotides appear to be the maximum deletion size. The cellular environment of contact-inhibited primary cell cultures or the myocardium in vivo is… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 24 references

The primary viruses of myocarditis

  • Kim, K.-S, K. Hofling, S. D. Carson, N. M. Chapman, S. Tracy
  • 2003

Similar Papers

Loading similar papers…