Replication of breast cancer susceptibility loci in whites and African Americans using a Bayesian approach.

  title={Replication of breast cancer susceptibility loci in whites and African Americans using a Bayesian approach.},
  author={Katie M O'Brien and Stephen R Cole and C. Poole and Jeannette T. Bensen and Amy H. Herring and Lawrence Stuart Engel and Robert C. Millikan},
  journal={American journal of epidemiology},
  volume={179 3},
Genome-wide association studies (GWAS) and candidate gene analyses have led to the discovery of several dozen genetic polymorphisms associated with breast cancer susceptibility, many of which are considered well-established risk factors for the disease. Despite attempts to replicate these same variant-disease associations in African Americans, the evaluable populations are often too small to produce precise or consistent results. We estimated the associations between 83 previously identified… CONTINUE READING
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