Replication of bovine herpesvirus type 4 in human cells in vitro.

@article{Egyed1998ReplicationOB,
  title={Replication of bovine herpesvirus type 4 in human cells in vitro.},
  author={L{\'a}szl{\'o} Egyed},
  journal={Journal of clinical microbiology},
  year={1998},
  volume={36 7},
  pages={
          2109-11
        }
}
A reference strain (Movár 33/63) of bovine herpesvirus type 4 (BHV-4) was inoculated into 14 different human cell lines and five primary cell cultures representing various human tissues. BHV-4 replicated in two embryonic lung cell lines, MRC-5 and Wistar-38, and in a giant-cell glioblastoma cell culture. Cytopathic effect and intranuclear inclusion bodies were observed in these cells. PCR detected a 10,000-times-higher level of BHV-4 DNA. Titration of the supernatant indicated a 100-fold… CONTINUE READING
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