Replication of adeno-associated virus type 2 in human lymphocytic cells and interaction with HIV-1.

@article{Mendelson1992ReplicationOA,
  title={Replication of adeno-associated virus type 2 in human lymphocytic cells and interaction with HIV-1.},
  author={Ella Mendelson and Zehave Grossman and Fernando Mileguir and Gideon Rechavi and Barrie J. Carter},
  journal={Virology},
  year={1992},
  volume={187 2},
  pages={453-63}
}
Adeno-associated virus (AAV) is a nonpathogenic parvovirus which normally requires helper adenovirus or herpes-virus for replication. We examined the growth of AAV type 2 in human lymphocytes and its possible interaction with HIV-1. Three B cell lines (CK-B, HS-2, and UC729) and four T cell lines (Molt-4, Jurkat, HUT78, and HUT78+HIV, which is persistently infected with HIV-1) were infected with AAV either in the presence or in the absence of adenovirus. AAV DNA was found in cells of all the… CONTINUE READING