Replication of a hepatitis A virus replicon detected by genetic recombination in vivo.

@article{GaussMller2002ReplicationOA,
  title={Replication of a hepatitis A virus replicon detected by genetic recombination in vivo.},
  author={Verena Gauss-M{\"u}ller and Yuri Y Kusov},
  journal={The Journal of general virology},
  year={2002},
  volume={83 Pt 9},
  pages={2183-92}
}
Unlike other picornaviruses, hepatitis A virus (HAV) replicates so inefficiently in cell culture that the study of its RNA biosynthesis presents a major experimental challenge. To assess viral RNA replication independent of particle formation, a subgenomic replicon representing a self-replicating RNA was constructed by replacing the P1 domain encoding the capsid proteins with the firefly luciferase sequence. Although translation of the HAV replicon was as efficient as a similar poliovirus… CONTINUE READING

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