Replication of a cis–syn thymine dimer at atomic resolution

@article{Ling2003ReplicationOA,
  title={Replication of a cis–syn thymine dimer at atomic resolution},
  author={Hong Ling and François Boudsocq and Brian S. Plosky and Roger Woodgate and Wei Yang},
  journal={Nature},
  year={2003},
  volume={424},
  pages={1083-1087}
}
Ultraviolet light damages DNA by catalysing covalent bond formation between adjacent pyrimidines, generating cis–syn cyclobutane pyrimidine dimers (CPDs) as the most common lesion. CPDs block DNA replication by high-fidelity DNA polymerases, but they can be efficiently bypassed by the Y-family DNA polymerase pol η. Mutations in POLH encoding pol η are implicated in nearly 20% of xeroderma pigmentosum, a human disease characterized by extreme sensitivity to sunlight and predisposition to skin… CONTINUE READING
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Crystal structure of the Escherichia coli dcm very-short-patch DNA repair endonuclease bound to its reaction product-site in a DNA superhelix

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Crystal structure of a DNA decamer containing a cis–syn thymine dimer

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