Replication of a cis–syn thymine dimer at atomic resolution

  title={Replication of a cis–syn thymine dimer at atomic resolution},
  author={Hong Ling and François Boudsocq and Brian S. Plosky and Roger Woodgate and Wei Yang},
Ultraviolet light damages DNA by catalysing covalent bond formation between adjacent pyrimidines, generating cis–syn cyclobutane pyrimidine dimers (CPDs) as the most common lesion. CPDs block DNA replication by high-fidelity DNA polymerases, but they can be efficiently bypassed by the Y-family DNA polymerase pol η. Mutations in POLH encoding pol η are implicated in nearly 20% of xeroderma pigmentosum, a human disease characterized by extreme sensitivity to sunlight and predisposition to skin… CONTINUE READING
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Crystal structure of the Escherichia coli dcm very-short-patch DNA repair endonuclease bound to its reaction product-site in a DNA superhelix

  • Bunting, A K.
  • Nucleic Acids Res
  • 2003

Crystal structure of a DNA decamer containing a cis–syn thymine dimer

  • H Park
  • Proc. Natl Acad. Sci. USA
  • 2002

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