Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages

@article{Wobus2004ReplicationON,
  title={Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages},
  author={C. Wobus and Stephanie M. Karst and L. Thackray and Kyeong-Ok Chang and S. Sosnovtsev and G. Belliot and A. Krug and J. Mackenzie and K. Green and H. Virgin},
  journal={PLoS Biology},
  year={2004},
  volume={2}
}
Noroviruses are understudied because these important enteric pathogens have not been cultured to date. We found that the norovirus murine norovirus 1 (MNV-1) infects macrophage-like cells in vivo and replicates in cultured primary dendritic cells and macrophages. MNV-1 growth was inhibited by the interferon-αβ receptor and STAT-1, and was associated with extensive rearrangements of intracellular membranes. An amino acid substitution in the capsid protein of serially passaged MNV-1 was… Expand
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