Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages

@article{Wobus2004ReplicationON,
  title={Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages},
  author={Christiane E Wobus and Stephanie M Karst and Larissa B. Thackray and Kyeong-Ok Chang and Stanislav V. Sosnovtsev and Ga{\"e}l Belliot and Anne B. Krug and Jason M Mackenzie and Kim Y Green and Herbert W Virgin},
  journal={PLoS Biology},
  year={2004},
  volume={2},
  pages={1001 - 1008}
}
Noroviruses are understudied because these important enteric pathogens have not been cultured to date. We found that the norovirus murine norovirus 1 (MNV-1) infects macrophage-like cells in vivo and replicates in cultured primary dendritic cells and macrophages. MNV-1 growth was inhibited by the interferon-alphabeta receptor and STAT-1, and was associated with extensive rearrangements of intracellular membranes. An amino acid substitution in the capsid protein of serially passaged MNV-1 was… CONTINUE READING
Highly Influential
This paper has highly influenced 35 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS