Replication of HIV-1 in vivo and in vitro.

@article{Orenstein2007ReplicationOH,
  title={Replication of HIV-1 in vivo and in vitro.},
  author={Jan Marc Orenstein},
  journal={Ultrastructural pathology},
  year={2007},
  volume={31 2},
  pages={151-67}
}
A complex relationship exists between HIV and its cellular targets. The lethal effect of HIV on circulating CD4(+) helper T lymphocytes parallels the degree of the infected individual's immunodeficiency and ultimately the transition to AIDS and death. However, as with other members of the Lentivirus family of retroviruses, the ubiquitous, mobile macrophage is also a prime target for HIV infection, and apparently, in most instances, is the initial infected cell, since most people are infected… CONTINUE READING

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