Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population.

@article{Jrvinen2012ReplicationOG,
  title={Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population.},
  author={Tiina M. J{\"a}rvinen and Anna Hellquist and Marco Zucchelli and Sari Koskenmies and Jaana Panelius and Taina Hasan and Heikki Julkunen and Mauro D'Amato and Juha Kere},
  journal={Rheumatology},
  year={2012},
  volume={51 1},
  pages={87-92}
}
OBJECTIVE A large number of genes, including several not previously implicated in SLE susceptibility, have recently been identified or confirmed by genome-wide association studies (GWAS). In this study, we sought to replicate some of these results in Finnish SLE patients (n = 275) and control individuals (n = 356). METHODS We genotyped 32 single nucleotide polymorphisms (SNPs) in 12 of the best-supported GWAS-identified SLE genes and loci. We further investigated gene-gene interactions… CONTINUE READING

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