Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels

@article{Osborne2016ReplicationOE,
  title={Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels},
  author={Lauren M. Osborne and Makena Clive and Mary C. Kimmel and Fiona E Gispen and Jerry Guintivano and Tori Brown and Olivia Cox and Jennifer Judy and Samantha Meilman and Aviva Braier and Matthias Wilhelm Beckmann and Johannes Kornhuber and Peter Andreas Fasching and Fernando S. Goes and Jennifer L. Payne and Elisabeth B. Binder and Zachary A. Kaminsky},
  journal={Neuropsychopharmacology},
  year={2016},
  volume={41},
  pages={1648-1658}
}
DNA methylation variation at HP1BP3 and TTC9B is modified by estrogen exposure in the rodent hippocampus and was previously shown to be prospectively predictive of postpartum depression (PPD) when modeled in antenatal blood. The objective of this study was to replicate the predictive efficacy of the previously established model in women with and without a previous psychiatric diagnosis and to understand the effects of changing hormone levels on PPD biomarker loci. Using a statistical model… 
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