Replication of Association of the PTPRC Gene With Response to Anti–Tumor Necrosis Factor Therapy in a Large UK Cohort

@inproceedings{Plant2012ReplicationOA,
  title={Replication of Association of the PTPRC Gene With Response to Anti–Tumor Necrosis Factor Therapy in a Large UK Cohort},
  author={Darren Plant and Rita Prajapati and Kimme L Hyrich and Ann W Morgan and Anthony Gerard Wilson and John Dudley Isaacs and Anne Barton},
  booktitle={Arthritis and rheumatism},
  year={2012}
}
OBJECTIVE Several rheumatoid arthritis (RA) susceptibility variants map close to genes involved in the tumor necrosis factor (TNF) signaling pathway, prompting the investigation of RA susceptibility variants in studies of predictors of response to TNF blockade. Based on a previously reported association of RA with the PTPRC genetic locus, the present study was undertaken to test established RA susceptibility variants, including PTPRC, in the prediction of response to TNF blockade in a large… CONTINUE READING
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