Replication of 6 Obesity Genes in a Meta-Analysis of Genome-Wide Association Studies from Diverse Ancestries

@inproceedings{Tan2014ReplicationO6,
  title={Replication of 6 Obesity Genes in a Meta-Analysis of Genome-Wide Association Studies from Diverse Ancestries},
  author={Li-jun Tan and Hu Zhu and Hao He and Ke-Hao Wu and Jian Li and Xiang-ding Chen and Ji-Gang Zhang and Hui Shen and Q. I. Tian and Marie Krousel-Wood and Christopher J. Papasian and Claude Bouchard and Louis P{\'e}russe and Hong-Wen Deng},
  booktitle={PloS one},
  year={2014}
}
Obesity is a major public health problem with a significant genetic component. Multiple DNA polymorphisms/genes have been shown to be strongly associated with obesity, typically in populations of European descent. The aim of this study was to verify the extent to which 6 confirmed obesity genes (FTO, CTNNBL1, ADRB2, LEPR, PPARG and UCP2 genes) could be replicated in 8 different samples (n = 11,161) and to explore whether the same genes contribute to obesity-susceptibility in populations of… CONTINUE READING
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