Replication occurs at a nucleoskeleton.

  title={Replication occurs at a nucleoskeleton.},
  author={David A. Jackson and Peter R. Cook},
  journal={The EMBO journal},
  volume={5 6},
The site of S-phase DNA synthesis has been the subject of recurring controversy. All recent evidence supporting a site fixed to some nuclear sub-structure is derived from studies in which cells or nuclei have been extracted in hypertonic salt concentrations. The controversy centres on whether the resulting nuclear matrices or cages have counterparts in vivo or are simply artefacts. Using isotonic conditions throughout the isolation and analytic procedures we have now reinvestigated the site of… CONTINUE READING