Replication mode and landscape topology differentially affect RNA virus mutational load and robustness.

@article{Sardanys2009ReplicationMA,
  title={Replication mode and landscape topology differentially affect RNA virus mutational load and robustness.},
  author={Josep Sardany{\'e}s and Ricard V. Sol{\'e} and Santiago F. Elena},
  journal={Journal of virology},
  year={2009},
  volume={83 23},
  pages={12579-89}
}
Regardless of genome polarity, intermediaries of complementary sense must be synthesized and used as templates for the production of new genomic strands. Depending on whether these new genomic strands become themselves templates for producing extra antigenomic ones, thus giving rise to geometric growth, or only the firstly synthesized antigenomic strands can be used to this end, thus following Luria's stamping machine model, the abundances and distributions of mutant genomes will be different… CONTINUE READING