Replication licensing promotes cyclin D1 expression and G1 progression in untransformed human cells.

@article{Liu2009ReplicationLP,
  title={Replication licensing promotes cyclin D1 expression and G1 progression in untransformed human cells.},
  author={Peijun Liu and Damien M. Slater and Marc E. Lenburg and Kathleen R. Nevis and Jeanette Gowen Cook and Cyrus Vaziri},
  journal={Cell cycle},
  year={2009},
  volume={8 1},
  pages={125-36}
}
Defects in DNA replication are implicated as early and causal events in malignancy. However, the immediate effects of impaired DNA replication licensing on cell cycle progression of non-malignant human cells are unknown. Therefore, we have investigated the acute effects of Mcm7 ablation using synchronized cultures of untransformed Human Dermal Fibroblasts (HDF). Mcm7 ablation elicited a G(1) delay associated with impaired activation of CDK4 and CDK2 and reduced Rb phosphorylation. The cell… CONTINUE READING

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