Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1

@article{lmezer2016ReplicationIT,
  title={Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1},
  author={Gizem {\"O}lmezer and Maryna Levikova and Dominique Klein and Beno{\^i}t Falquet and Gabriele A Fontana and Petr Cejka and Ulrich Rass},
  journal={Nature Communications},
  year={2016},
  volume={7}
}
Cells have evolved mechanisms to protect, restart and repair perturbed replication forks, allowing full genome duplication, even under replication stress. Interrogating the interplay between nuclease-helicase Dna2 and Holliday junction (HJ) resolvase Yen1, we find the Dna2 helicase activity acts parallel to homologous recombination (HR) in promoting DNA replication and chromosome detachment at mitosis after replication fork stalling. Yen1, but not the HJ resolvases Slx1-Slx4 and Mus81-Mms4… 

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