Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity

  title={Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity},
  author={John Shiver and Tong-Ming Fu and Ling Chen and Danilo R. Casimiro and M C Davies and Robert K. Evans and Z J Zhang and Adam J. Simon and Wendy L. Trigona and Sheri A. Dubey and Lingyi Huang and Virginia A. Harris and Romnie S. Long and Xiaoping Liang and Larry K Handt and William A. Schleif and Lan Zhu and Daniel C. Freed and Natasha V. Persaud and Liming Guan and Kara S. Punt and Aimin Tang and Minchun Chen and Keith A A Wilson and Kelly B. Collins and Gwendolyn J. Heidecker and Virginia R Fernandez and Helen C. Perry and Joseph G. Joyce and Karen M. Grimm and James C. Cook and Paul M. Keller and Denise S. Kresock and Henryk Mach and Robert D. Troutman and Lynne A. Isopi and Donna M. Williams and Zheng Xu and Kathryn E. Bohannon and David B. Volkin and David C. Montefiori and Ayako Miura and Georgia R. Krivulka and Michelle A. Lifton and Marcelo J. Kuroda and Joern E Schmitz and Norman L. Letvin and Michael J. Caulfield and Andrew J. Bett and Rima Youil and David C Kaslow and Emilio A. Emini},
Recent studies of human immunodeficiency virus type 1 (HIV-1) infection in humans and of simian immunodeficiency virus (SIV) in rhesus monkeys have shown that resolution of the acute viral infection and control of the subsequent persistent infection are mediated by the antiviral cellular immune response. We comparatively assessed several vaccine vector… CONTINUE READING