Replication forks are not found in a Drosophila minichromosome demonstrating a gradient of polytenization

@article{Glaser1992ReplicationFA,
  title={Replication forks are not found in a Drosophila minichromosome demonstrating a gradient of polytenization},
  author={Robert L. Glaser and Gary H. Karpen and Allan C Spradling},
  journal={Chromosoma},
  year={1992},
  volume={102},
  pages={15-19}
}
Differential DNA replication is widely held to influence polytene chromosome structure by causing the dramatic reductions in heterochromatic DNA content that are characteristic of most endopolyploid cells. The “underreplication model” of heterochromatic sequence underrepresentation predicts that replication intermediates should populate regions of DNA between fully polytenized euchromatic sequences and underpolytenized heterochromatic sequences. We directly tested this prediction using Dp1187… CONTINUE READING

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