Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway

@article{Franchitto2008ReplicationFS,
  title={Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway},
  author={Annapaola Franchitto and Livia Maria Pirzio and Ennio Prosperi and Orazio Sapora and Margherita Bignami and Pietro Pichierri},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={183},
  pages={241 - 252}
}
Failure to stabilize and properly process stalled replication forks results in chromosome instability, which is a hallmark of cancer cells and several human genetic conditions that are characterized by cancer predisposition. Loss of WRN, a RecQ-like enzyme mutated in the cancer-prone disease Werner syndrome (WS), leads to rapid accumulation of double-strand breaks (DSBs) and proliferating cell nuclear antigen removal from chromatin upon DNA replication arrest. Knockdown of the MUS81… CONTINUE READING