Replication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract.

Abstract

DNA sequences prone to forming noncanonical structures (hairpins, triplexes, G-quadruplexes) cause DNA replication fork stalling, activate DNA damage responses, and represent hotspots of genomic instability associated with human disease. The 88-bp asymmetric polypurine-polypyrimidine (Pu-Py) mirror repeat tract from the human polycystic kidney disease (PKD1… (More)

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Cite this paper

@article{Liu2012ReplicationFS, title={Replication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract.}, author={Guoqi Liu and Sher{\'e} Myers and Xiaomi Chen and John J. Bissler and Richard R. Sinden and M. Leffak}, journal={The Journal of biological chemistry}, year={2012}, volume={287 40}, pages={33412-23} }