Replication fork passage drives asymmetric dynamics of a critical nucleoid-associated protein in Caulobacter.

@article{AriasCartin2017ReplicationFP,
  title={Replication fork passage drives asymmetric dynamics of a critical nucleoid-associated protein in Caulobacter.},
  author={Rodrigo Arias-Cartin and Genevieve S Dobihal and Manuel Ant{\'o}nio Campos and Ivan Vladimirovich Surovtsev and Bradley Parry and Christine Jacobs-Wagner},
  journal={The EMBO journal},
  year={2017},
  volume={36 3},
  pages={301-318}
}
In bacteria, chromosome dynamics and gene expression are modulated by nucleoid-associated proteins (NAPs), but little is known about how NAP activity is coupled to cell cycle progression. Using genomic techniques, quantitative cell imaging, and mathematical modeling, our study in Caulobacter crescentus identifies a novel NAP (GapR) whose activity over the cell cycle is shaped by DNA replication. GapR activity is critical for cellular function, as loss of GapR causes severe, pleiotropic defects… CONTINUE READING