Replication fork collisions cause pathological chromosomal amplification in cells lacking RecG DNA translocase

@inproceedings{Rudolph2009ReplicationFC,
  title={Replication fork collisions cause pathological chromosomal amplification in cells lacking RecG DNA translocase},
  author={Christian J Rudolph and A Louise Upton and R. G. Lloyd},
  booktitle={Molecular microbiology},
  year={2009}
}
Duplication and transmission of chromosomes require precise control of chromosome replication and segregation. Here we present evidence that RecG is a major factor influencing these processes in bacteria. We show that the extensive DnaA-independent stable DNA replication observed without RecG can lead to replication of any area of the chromosome. This replication is further elevated following irradiation with UV light and appears to be perpetuated by secondary events that continue long after… CONTINUE READING
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