Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.

@article{Ludmerer2005ReplicationFA,
  title={Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.},
  author={Steven W. Ludmerer and Donald J. Graham and Evelyn Boots and Edward M. Murray and Amy L. Simcoe and Eric Markel and Jay Alan Grobler and Osvaldo A. Flores and David Brian Olsen and Daria Hazuda and Robert L. Lafemina},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 5},
  pages={
          2059-69
        }
}
The innate genetic variability characteristic of chronic hepatitis C virus (HCV) infection makes drug resistance a concern in the clinical development of HCV inhibitors. To address this, a transient replication assay was developed to evaluate the replication fitness and the drug sensitivity of NS5B sequences isolated from the sera of patients with chronic HCV infection. This novel assay directly compares replication between NS5B isolates, thus bypassing the potential sequence and metabolic… CONTINUE READING

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