Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication

@inproceedings{Rajala2014ReplicationFT,
  title={Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication},
  author={Nina K.M. Rajala and Joachim M Gerhold and Peter Martinsson and Alexey Klymov and Johannes N. Spelbrink},
  booktitle={Nucleic acids research},
  year={2014}
}
Mitochondrial DNA (mtDNA) is organized in discrete protein-DNA complexes, nucleoids, that are usually considered to be mitochondrial-inner-membrane associated. Here we addressed the association of replication factors with nucleoids and show that endogenous mtDNA helicase Twinkle and single-stranded DNA-binding protein, mtSSB, co-localize only with a subset of nucleoids. Using nucleotide analogs to identify replicating mtDNA in situ, the fraction of label-positive nucleoids that is Twinkle/mtSSB… CONTINUE READING
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