Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: efficient human cell infection and bypass of preexisting adenovirus immunity.

@article{Vogels2003ReplicationdeficientHA,
  title={Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: efficient human cell infection and bypass of preexisting adenovirus immunity.},
  author={Ronald Vogels and David Zuijdgeest and Richard van Rijnsoever and Eric Hartkoorn and Irma Damen and Marie-Pierre P de B{\'e}thune and Stefan Kostense and Germaine Penders and Niels Helmus and Wouter Koudstaal and Marco Cecchini and Antoinette Wetterwald and M. A. G. Sprangers and Angelique A. C. Lemckert and Olga Jae Ophorst and B F Koel and Michelle van Meerendonk and Paul H A Quax and Laura Panitti and J. Grimbergen and A. Bout and Jaap Goudsmit and Menzo J.E. Havenga},
  journal={Journal of virology},
  year={2003},
  volume={77 15},
  pages={
          8263-71
        }
}
Replication-deficient human adenovirus type 5 (Ad5) can be produced to high titers in complementing cell lines, such as PER.C6, and is widely used as a vaccine and gene therapy vector. However, preexisting immunity against Ad5 hampers consistency of gene transfer, immunological responses, and vector-mediated toxicities. We report the identification of human Ad35 as a virus with low global prevalence and the generation of an Ad35 vector plasmid system for easy insertion of heterologous genes. In… CONTINUE READING

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