Replication-defective adenovirus vectors with multiple deletions do not induce measurable vector-specific T cells in human trials.

@article{Koup2009ReplicationdefectiveAV,
  title={Replication-defective adenovirus vectors with multiple deletions do not induce measurable vector-specific T cells in human trials.},
  author={Richard A. Koup and Laurie Lamoreaux and David Zarkowsky and Robert T. Bailer and C. Richter King and Jason G. D. Gall and D. Brough and Barney S. Graham and Mario Roederer},
  journal={Journal of virology},
  year={2009},
  volume={83 12},
  pages={6318-22}
}
The magnitude and character of adenovirus serotype 5 (Ad5)-specific T cells were determined in volunteers with and without preexisting neutralizing antibodies (NAs) to Ad5 who received replication-defective Ad5 (rAd5)-based human immunodeficiency virus vaccines. There was no correlation between T-cell responses and NAs to Ad5. There was no increase in magnitude or activation state of Ad5-specific CD4(+) T cells at time points where antibodies to Ad5 and T-cell responses to the recombinant gene… CONTINUE READING

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