Replication and preferential inheritance of hypersuppressive petite mitochondrial DNA.

@article{MacAlpine2001ReplicationAP,
  title={Replication and preferential inheritance of hypersuppressive petite mitochondrial DNA.},
  author={David M. MacAlpine and Jill L Kolesar and Kozi Okamoto and Ronald A. Butow and Philip S. Perlman},
  journal={The EMBO journal},
  year={2001},
  volume={20 7},
  pages={1807-17}
}
Wild-type yeast mitochondrial DNA (mtDNA) is inherited biparentally, whereas mtDNA of hypersuppressive petite mutants is inherited uniparentally in crosses to strains with wild-type mtDNA. Genomes of hypersuppressive petites contain a conserved ori sequence that includes a promoter, but it is unclear whether the ori confers a segregation or replication advantage. Fluorescent in situ hybridization analysis of wild-type and petite mtDNAs in crosses reveals no preferential segregation of… CONTINUE READING

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