Replication and packaging of Norwalk virus RNA in cultured mammalian cells.

@article{Asanaka2005ReplicationAP,
  title={Replication and packaging of Norwalk virus RNA in cultured mammalian cells.},
  author={Miyuki Asanaka and Robert L. Atmar and Vivian Ruvolo and Sue E. S. Crawford and Frederick H. Neill and Mary K. Estes},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 29},
  pages={10327-32}
}
Human noroviruses, the most common cause of nonbacterial gastroenteritis, are characterized by high infectivity rate, low infectious dose, and unusually high stability outside the host. However, human norovirus research is hindered by the lack of a cell culture system and a small animal model of infection. Norwalk virus (NV) is the prototype strain of human noroviruses. We report here replication of NV viral RNA and its packaging into virus particles in mammalian cells by intracellular… CONTINUE READING