Replication and extension of association of choline acetyltransferase with nicotine dependence in European and African American smokers

@article{Wei2010ReplicationAE,
  title={Replication and extension of association of choline acetyltransferase with nicotine dependence in European and African American smokers},
  author={Jinxue Wei and Jennie Z Ma and Thomas J. Payne and Wenyan Cui and Riju Ray and Nandita Mitra and Caryn Lerman and Ming D. Li},
  journal={Human Genetics},
  year={2010},
  volume={127},
  pages={691-698}
}
Choline acetyltransferase is critical in the synthesis of acetylcholine and regulation of cholinergic neuron functions. We recently reported association of the encoding gene ChAT with both smoking cessation and nicotine dependence (ND) in two independent European American (EA) samples; however, in the replication sample, only limited SNPs partially covering the gene were examined. In this study, we examined the association of 14 SNPs, which cover the entire gene, with ND, assessed by smoking… CONTINUE READING

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