Replication and cytolysis of an E1B-attenuated adenovirus in drug-resistant ovarian tumour cells is associated with reduced apoptosis

@article{Ganly2001ReplicationAC,
  title={Replication and cytolysis of an E1B-attenuated adenovirus in drug-resistant ovarian tumour cells is associated with reduced apoptosis},
  author={Ian Ganly and YT Kim and Byron Hann and Alan Balmain and Robert Brown},
  journal={Gene Therapy},
  year={2001},
  volume={8},
  pages={369-375}
}
Therapeutic approaches which are effective in tumour cells resistant to conventional chemotherapy would be of value. An E1B 55 kDa-deleted adenovirus (ONYX-015) induces lysis in cells with mutant p53, although the specificity of these observations for different cell types is unclear. We have used a matched set of drug-resistant human ovarian tumour cell… CONTINUE READING