Replication and Expression Strategies of Viruses

@article{Rampersad2018ReplicationAE,
  title={Replication and Expression Strategies of Viruses},
  author={S S Rampersad and Paula F. Tennant},
  journal={Viruses},
  year={2018},
  pages={55 - 82}
}

Short and Sweet: Viral 5`-UTR as a Canonical and Non-Canonical Translation Initiation Switch

TLDR
Cap-dependent and cap-independent translation initiation mechanisms are summarized and the unique ability of the BBV mRNA 5’-UTR to switch between these two modes of translation initiation in the context of the viral life cycle is elaborated.

Top Three Strategies of ss(+)RNA Plant Viruses: Great Opportunists and Ecosystem Tuners with a Small Genome

TLDR
RNA viruses are increasingly treated not as micropathogens but as necessary regulators of ecosystem balance, and a fundamental understanding of this aspect of the role played by viruses in the ecosystem makes it possible to apply this knowledge to the creation of DNA insecticides.

Computational Prediction of Bacteriophage Host Ranges

TLDR
Recently developed bioinformatic tools are reviewed that offer a promising and high-throughput alternative by computationally predicting the putative host ranges of bacteriophages, including those challenging to grow in laboratory environments.

The Impact of Epitranscriptomics on Antiviral Innate Immunity

TLDR
At the virological level, epitranscriptomics can thus directly impact the viral life cycle itself, acting on viral or cellular proteins promoting replication, or impacting the innate antiviral response of the host cell, the latter being the focus of the present review.

Temperature modulates immune gene expression in mosquitoes during arbovirus infection

TLDR
Temperature significantly modulates mosquito gene expression in response to infection, potentially leading to impairment of immune defences at higher temperatures.

Potential Antiviral Action of Alkaloids

TLDR
Overall, the influence of alkaloids at the molecular level suggests a high degree of specificity which means they could serve as potent and safe antiviral agents waiting for evaluation and exploitation.

SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis

  • Chao QinYouliang Rao P. Feng
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2022
TLDR
It is reported that SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis, and inhibition of a key metabolic enzyme not only depletes the nucleotide pool but also restores host inflammatory defense, thereby effectively impeding Sars-Cov-2 replication.

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TLDR
The present review summarizes the genetic organization and expression strategies of human complex retroviruses and highlights the converging mechanisms controlling their life cycles.

Strategies in subversion: de‐regulation of the mammalian cell cycle by viral gene products

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