Replication and Expression Strategies of Viruses

  title={Replication and Expression Strategies of Viruses},
  author={S S Rampersad and Paula F. Tennant},
  pages={55 - 82}
Summary Regardless of their genetic constitution, viral genomes are replicated, expressed, and assembled in association with living host cells. These entities do not undergo division, but rather generate new particles through the assembly of preformed components. Some viruses go further by modifying cellular metabolism to create a more favorable environment for viral gene expression. In a few instances, these clever strategies also facilitate escape from the host’s defense responses. The… Expand
4 Citations
Prospects for viruses infecting eukaryotic microalgae in biotechnology.
A short review of what is known about viruses infecting eukaryotic microalgae, and how acknowledging their importance can shape future research focussed not only on marine ecology and evolutionary biology but also on biotechnological applications related toMicroalgae cell factories. Expand
Temperature modulates immune gene expression in mosquitoes during arbovirus infection
Temperature significantly modulates mosquito gene expression in response to infection, potentially leading to impairment of immune defences at higher temperatures. Expand
Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic
It is revealed that the proposed plant metabolites can serve as potential anti- SARS-CoV-2 lead molecules for further optimization and drug development processes to combat COVID-19 and future pandemics caused by viruses. Expand
Unorthodox features in two venerid bivalves with doubly uniparental inheritance of mitochondria
The complete sex-specific mtDNAs of two recently-discovered DUI species in two families of the order Venerida, Scrobicularia plana (Semelidae) and Limecola balthica (Tellinidae) are presented, indicating that general mitochondrial features are shared among DUI species. Expand


Virus manipulation of cell cycle
Taking the maxim “Set a thief to catch a thief” as a counter strategy provides the very same virus evasion strategies as “ready-made tools” for the development of novel antivirus therapeutics. Expand
Cytoplasmic Viruses: Rage against the (Cellular RNA Decay) Machine
This review describes the myriad ways that viruses deal with the general host RNA decay machinery that is active in the cell immediately upon viral infection—turning what, at first, appears to be very hostile territory for a foreign transcript into a sort of “promised land” for viral gene expression. Expand
Adenovirus DNA replication.
The development of antivirals that interfere with human adenovirus replication and the impact of HAdV on human disease are covered. Expand
The role of the influenza virus RNA polymerase in host shut-off
It is found that Pol II is ubiquitylated in influenza virus infected cells and ubiquitylation can be induced by the expression of the RNA polymerases, and that the viral RNA polymerase plays a critical role in this process. Expand
Influenza Viruses and mRNA Splicing: Doing More with Less
The ability of IAV to be well adapted to the host’s splicing machinery is emphasized, and further investigations may contribute to a better understanding of splicing regulation with regard to viral replication, host range, and pathogenesis. Expand
Viral Subversion of Nucleocytoplasmic Trafficking
This review explores the importance of nucleocytoplasmic trafficking to viral pathogenesis as these studies revealed new antiviral therapeutic strategies and exposed previously unknown cellular mechanisms. Expand
A Common Strategy for Host RNA Degradation by Divergent Viruses
Multiple host shutoff factors have converged upon a common mRNA degradation pathway, and each targets translatable RNAs for cleavage and requires host Xrn1 to complete RNA degradation, although the mechanism of targeting and the position of the primary cleavage differ. Expand
Converging Strategies in Expression of Human Complex Retroviruses
The present review summarizes the genetic organization and expression strategies of human complex retroviruses and highlights the converging mechanisms controlling their life cycles. Expand
Strategies in subversion: de‐regulation of the mammalian cell cycle by viral gene products
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