Replication Timing: A Fingerprint for Cell Identity and Pluripotency

Abstract

Many types of epigenetic profiling have been used to classify stem cells, stages of cellular differentiation, and cancer subtypes. Existing methods focus on local chromatin features such as DNA methylation and histone modifications that require extensive analysis for genome-wide coverage. Replication timing has emerged as a highly stable cell type-specific… (More)
DOI: 10.1371/journal.pcbi.1002225

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