Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase

@article{Semlow2016ReplicationDependentUO,
  title={Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase},
  author={Daniel R. Semlow and Jieqiong Zhang and Magda Budzowska and Alexander C. Drohat and Johannes C. Walter},
  journal={Cell},
  year={2016},
  volume={167},
  pages={498-511.e14}
}
During eukaryotic DNA interstrand cross-link (ICL) repair, cross-links are resolved ("unhooked") by nucleolytic incisions surrounding the lesion. In vertebrates, ICL repair is triggered when replication forks collide with the lesion, leading to FANCI-FANCD2-dependent unhooking and formation of a double-strand break (DSB) intermediate. Using Xenopus egg extracts, we describe here a replication-coupled ICL repair pathway that does not require incisions or FANCI-FANCD2. Instead, the ICL is… CONTINUE READING
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