Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism

@inproceedings{Dhamne2017ReplicableIV,
  title={Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism},
  author={Sameer C. Dhamne and Jill L Silverman and Chloe E Super and Stephen H T Lammers and Mustafa Q Hameed and Meera E. Modi and Nycole A. Copping and Michael C. Pride and Daniel G Smith and Alexander Rotenberg and Jacqueline N. Crawley and Mustafa Sahin},
  booktitle={Molecular Autism},
  year={2017}
}
BackgroundAutism spectrum disorder (ASD) is a clinically and biologically heterogeneous condition characterized by social, repetitive, and sensory behavioral abnormalities. No treatments are approved for the core diagnostic symptoms of ASD. To enable the earliest stages of therapeutic discovery and development for ASD, robust and reproducible behavioral phenotypes and biological markers are essential to establish in preclinical animal models. The goal of this study was to identify… CONTINUE READING

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