Replicability Analysis for Genome-wide Association Studies

  title={Replicability Analysis for Genome-wide Association Studies},
  author={Ruth Heller and Daniel Yekutieli},
The paramount importance of replicating associations is well recognized in the genome-wide associaton (GWA) research community, yet methods for assessing replicability of associations are scarce. Published GWA studies often combine separately the results of primary studies and of the follow-up studies. Informally, reporting the two separate meta-analyses, that of the primary studies and follow-up studies, gives a sense of the replicability of the results. We suggest a formal empirical Bayes… CONTINUE READING