Replica model for an unusual directed polymer in 1+1 dimensions and prediction of the extremal parameter of gapped sequence alignment statistics.

@article{Yu2004ReplicaMF,
  title={Replica model for an unusual directed polymer in 1+1 dimensions and prediction of the extremal parameter of gapped sequence alignment statistics.},
  author={Yi-Kuo Yu},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  year={2004},
  volume={69 6 Pt 1},
  pages={
          061904
        }
}
Sequence alignment is one of the most important bioinformatics tools for modern molecular biology. The statistical characterization of gapped alignment scores has been a long-standing problem in sequence alignment research. In this paper, we provide a self-contained exposition of sequence alignment, a short review about how this problem is related to the directed polymer problem in statistical physics, and some analytical results that can be used for predicting alignment score statistics… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.

Toward an accurate statistics of gapped alignments

VIEW 1 EXCERPT
CITES BACKGROUND