Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents preexisting immunity to adenovirus in mice.

@article{Shiratsuchi2010ReplacingAV,
  title={Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents preexisting immunity to adenovirus in mice.},
  author={Takayuki Shiratsuchi and Urvashi Rai and Anja Krause and Stefan Worgall and Moriya Tsuji},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 10},
  pages={3688-701}
}
Although adenovirus (Ad) has been regarded as an excellent vaccine vector, there are 2 major drawbacks to using this platform: (a) Ad-based vaccines induce a relatively weak humoral response against encoded transgenes, and (b) preexisting immunity to Ad is highly prevalent among the general population. To overcome these obstacles, we constructed an Ad-based malaria vaccine by inserting a B cell epitope derived from a Plasmodium yoelii circumsporozoite (CS) protein (referred to as the PyCS-B… CONTINUE READING

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