Replacing, reducing and refining the use of animals in tuberculosis vaccine research.

Abstract

Tuberculosis (TB) remains a serious global health threat and an improved vaccine is urgently needed. New candidate TB vaccines are tested using preclinical animal models such as mice, guinea pigs, cattle and non-human primates. Animals are routinely infected with virulent Mycobacterium tuberculosis (Mtb) in challenge experiments to evaluate protective… (More)
DOI: 10.14573/altex.1607281

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