Replacement therapy of oral hydrocortisone in adrenal insufficiency: the influence of gastrointestinal factors

@article{Lennerns2008ReplacementTO,
  title={Replacement therapy of oral hydrocortisone in adrenal insufficiency: the influence of gastrointestinal factors},
  author={Hans Lennern{\"a}s and Stanko Skrtic and Gudmundur Johannsson},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  year={2008},
  volume={4},
  pages={749 - 758}
}
Background: Replacing glucocorticoids in primary adrenal insufficiency (AI) or Addison's disease (AD) is today based on oral replacement therapy with hydrocortisone in a conventional immediate-release tablet. It is recognised that physiological gastrointestinal factors may have a strong influence on the plasma concentration-time profile of hydrocortisone. Hydrocortisone has a sufficiently high permeability in both the small and large intestine, but in vivo dissolution from the available oral… 

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